Teaching MCC CUREs
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Information here will be used at the 2025 MCC Fellows Cohort and Professional Development Workshop in San Diego
MCC PyMOL Homework (Prof Dev):
1) Review the PDB files in this handout. IF you are already familiar with PyMOL or another rendering program - play with one or more of the MDH structures. If not - there are a series of links to videos you can use developed by Lisa Gentile. Another set of very good videos are hosted on YouTube by Kristin Procko on her “molecular memory” website. Look at the PyMol 101 series. Her other series has additional information as well.PreVirtual Homework (Cohort):
1) If you haven’t already, get an account for mdhcures.org>MCC members only pages https://www.mdhcures.org/mcc-members-only
3) Watch theLoop mutation video
4) Watch video about phosphomimic mutations(Min 1-8 and 40-51)Virtual Workshop Agenda
Hour one: 10 -11 EDT / 9-10 CDT Welcome, introductions, what and why a CURE? (Joe)Why MDH, resources and website intro (Joe)Role of mentors and the plan to pair cohort members (Amy)Testimony/Witness the benefits of MCC/CUREs (Previous cohort)
Hour two: 11-12 EDT/ 10-11 AM CDT... 8-9 PDT
Key elements of a CURE and Hypothesis development (Kevin)
Cohort MDH CURE project ideas: Loop domain studies/ unanswered questions (Ellis)
Cohort MDH CURE project ideas: Phosphomimetic studies/ unanswered questions (Amy)
Questions to ask in the process of creating your CURE - sketching out plans (Amy)
Break: 1.5 hours -sketch out course plan/ questions – lunch
Hour three: 1:30-245 EDT / 12:30-1:45 CDT….10:30 -1145 PDT
MDH structure and function of MDH (Jess)MDH mini-reviews - overview of the resource (Amy)How to plan a semester/syllabus Full or Modular CURE (Ellis)
5 min break
Hour four: 2:45- 3:30 EDT/1:45-2:30 CDT ...11:45-12:30 PDT
MDH beyond the CURE (Varuni)Lessons learned, Tips and advice (Mentors and previous cohort members)
Hour five: 3:30-4:30 EDT/2:30-3:30 CDT...12:30-1:30 PDT
Small group breakout with mentors to plan out ideas for your CURE/syllabus (will be further developed at in-person workshop).
~30 minLogistics about travel and in-person agenda (Joe)
In-Person COHORT and Prof Dev AGENDA IN DEVELOPMENT
MDH and VR
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Research Elements of an MDH CURE
OUR Community Key Component Expanded Description
CURES to teach Biological Thinking (Bell BAMBED 2020)
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Community College
Primarily Undergraduate Institution
Comprehensive and R1 University
First Year Chem & Biol
First Year Chem - Full Semester Drug Design
First Year Chem -Modular MDH & Cancer
Hybrid and Virtual
Have a syllabi or link to your MDH CURE you want to share? Email your hub leader (Ellis Bell, Lisa Gentile Amy Springer) or Joseph Provost.
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Publications (papers and reviews)
CUREs in biochemistry-where we are and where we should go
Development and Use of CUREs in Biochemistry
External Collaboration Results in Student Learning Gains and Positive STEM Attitudes in CUREs
Developing Course Undergraduate Research Experiences (CUREs) in Chemistry
Project: Malate Dehydrogenase CURE Community
Abstracts
The Evolution of the Malate Dehydrogenase CUREs Community
Protein Engineering of a Spectroscopic Probe into Malate Dehydrogenase (MDH)
MDH CURE Community Faculty Fellows: A new mentoring program supporting Biochemistry CUREs
OTHER
AddGene Course-Based Undergraduate Research Experiences (CUREs)
Send J Provost links to your publications, abstracts or other materials to include on this page.
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Tips and Hints to Teaching a CURE
Student Handout - Hypothesis Development MDH-CS Interaction
MDH Phosphorylation - Gen Chem Materials (go to members only)
MCC Discount at BioRad (Save up to 60% off Bio-Rad list prices! MCC is a Bio-Rad Explorer education program preferred pricing partner and members can receive additional discounts on equipment, reagents, and consumables for their MCC courses – Go to the Members Only Page to find links to save!)
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Using Metabolons in MDH CUREs
More CURE Links
OUR CURES
CUREnet
BASIL
CRISPR CURES