MDH: BACKGROUND

Malate Dehydrogenase is a simple redox reaction recognizable to students from the tricarboxylic acid cycle.  However, MDH plays a much more complicated role in a range of metabolic pathways supporting cellular function in a variety of states and organisms.  This diversity of metabolic roles and the regulation of its function make MDH a nearly endless source of interesting untapped research projects.  This is page contains the basics of MDH structure function and published works.

GENERAL BACKGROUND (FACULTY ONLY: PASSWORD REQUIRED: CONTACT ELLIS BELL, JBELL@SANDIEGO.EDU TO REGISTER FOR A PASSWORD TO ACCESS THIS MATERIAL)

You will find the following sections:

  • A Brief Introduction to Malate Dehydrogenase

  • Introduction to the Role of the Active Site Loop Region of watermelon glyoxysomal MDH

  • Allosteric Regulation and Malate Dehydrogenases

  • Mammalian MDH Metabolism, Disease

  • Mammalian MDH Expression, Structure & Kinetics.   

  • Mammalian MDH Structure, Mechanism and Kinetics

  • Mammalian MDH and Hydroxyglutarate Metabolism

  • MDH Post Translational Modification: Phosphorylation, Methylation and Acetylation

  • MDH Protein-Protein Interactions

GENERAL LINKS/RESOURCES

HELPFUL PUBLICATIONS

BACKGROUND

KINETICS AND MECHANISM

SELECT PUBLICATIONS OF INTEREST